Heterogeneous H-Bonding in a Foldamer Helix
نویسندگان
چکیده
منابع مشابه
Switching the H-bonding network of a foldamer by modulating the backbone chirality and constitutional ratio of amino acids.
This communication describes the folding propensity of a heterofoldamer motif featuring proline (Pro) and anthranilic acid (Ant) residues in a 1:2:1 (α:β:α) constitutional ratio. Structural investigations unequivocally suggest that the hydrogen-bonding network of this foldamer motif can be switched between 9-membered and 6-membered by modulating the backbone chirality and constitutional ratio o...
متن کاملIn situ iodination and X-ray crystal structure of a foldamer helix bundle.
We report here the efficient in situ iodination of tyrosine-type side-chains located within a foldamer helix bundle, permitting structure determination using single-wavelength anomalous diffraction (SAD) methods. We suggest that this simple method may be of use to those engaged in structural foldamer research as a potential solution to the phase problem.
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Specific stimuli such as intracellular H+ and phosphoinositides (e.g., PIP2) gate inwardly rectifying potassium (Kir) channels by controlling the reversible transition between the closed and open states. This gating mechanism underlies many aspects of Kir channel physiology and pathophysiology; however, its structural basis is not well understood. Here, we demonstrate that H+ and PIP2 use a con...
متن کاملRevisiting the Ramachandran plot: hard-sphere repulsion, electrostatics, and H-bonding in the alpha-helix.
What determines the shape of the allowed regions in the Ramachandran plot? Although Ramachandran explained these regions in terms of 1-4 hard-sphere repulsions, there are discrepancies with the data where, in particular, the alphaR, alphaL, and beta-strand regions are diagonal. The alphaR-region also varies along the alpha-helix where it is constrained at the center and the amino terminus but d...
متن کاملHeterogeneous Channel Bonding Revisited
Efficient communication in distributed systems is essential for optimal system performance. As parallel computation develops, many different kinds of messages need to be sent between machines. These messages may have different requirements for network latency and bandwidth. In this paper, we revisit combining two physical interfaces into one virtual network (channel bonding).In contrast with mo...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2015
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.5b03382